Characterization of Viral Insulin/IGF-1-like Peptides (VILPs)

Our recent and exciting discovery has unveiled that viruses carry sequences strikingly similar to human peptide hormones. Specifically, we’ve identified six VILPs within the Iridoviridae virus family. In this comprehensive project, our aim is to comprehend how VILPs interact with the insulin/IGF-1 system, influencing receptors, downstream signaling, and related functions. We’ve already uncovered unique functions of VILPs including IGF-1 receptor inhibition. Furthermore, we’re delving into the role of VILPs in host-pathogen interactions using the Grouper Iridovirus and zebrafish as model systems. 

The Role of Gut Microbiome in Autoimmunity

As autoimmune diseases become more prevalent and genetics alone can’t explain their rise, attention has turned to environmental factors, including gut microbes and their products. We’re actively investigating the role of gut microbes and their products in the autoimmunity of Type 1 Diabetes and Celiac Disease. To explore this, we’re utilizing patient samples and mouse models of these diseases. Our focus includes understanding the molecular mimicry mechanism, examining specific bacterial species like Parabacteroides distasonis, and studying gut microbiota-derived metabolites. We’re also embracing innovative approaches like IgA-sequencing and Pep-Seq to deepen our understanding of the interactions between the microbiome and the host.